LenSen Extra/LenSen Forte Drug Interactions

Paracetamol: Increased Effect/Toxicity: Barbiturates, carbamazepine, hydantoins, isoniazid, rifampin, sulfinpyrazone may increase the hepatotoxic potential of acetaminophen; chronic ethanol abuse increases risk for acetaminophen toxicity; effect of warfarin may be enhanced.
Decreased Effect: Barbiturates, carbamazepine, hydantoins, rifampin, sulfinpyrazone may decrease the analgesic effect of acetaminophen; cholestyramine may decrease acetaminophen absorption (separate dosing by at least 1 hour).
Ibuprofen: Increased Effect/Toxicity: Ibuprofen may increase cyclosporine, digoxin, lithium, and methotrexate serum concentrations. The renal adverse effects of ACE inhibitors may be potentiated by NSAIDs. Corticosteroids may increase the risk of GI ulceration.
Decreased Effect: Aspirin may decrease ibuprofen serum concentrations. Ibuprofen may decrease the effect of some antihypertensive agents (including ACE inhibitors and angiotensin antagonists) and diuretics.